AHEART April 47/4
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چکیده
Maulik, Nilanjana, Tetsuya Yoshida, Richard M. Engelman, Debasis Bagchi, Hajime Otani, and Dipak K. Das. Dietary coenzyme Q10 supplement renders swine hearts resistant to ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 278: H1084–H1090, 2000.—To examine whether nutritional supplementation of coenzyme Q10 (CoQ10) can reduce myocardial ischemia-reperfusion injury, a group of swine was fed a regular diet supplemented with CoQ10 (5 mg·kg21 ·day21) for 30 days. Another group of pigs that were fed a regular diet supplemented with placebo served as a control. After 30 days, isolated in situ pig hearts were prepared and hearts were perfused with a cardiopulmonary pump system. Each heart was subjected to 15 min of regional ischemia by snaring of the left anterior descending coronary artery, followed by 60 min of hypothermic cardioplegic global ischemia and 120 min of reperfusion. After the experiments were completed, myocardial infarct size was measured by triphenyltrazolium chloride staining methods. Postischemic left ventricular contractile function was better recovered in the CoQ10 group than in the control group of pigs. CoQ10-fed pigs revealed less myocardial infarction and less creatine kinase release from the coronary effluent compared with control pigs. The experimental group also demonstrated a smaller amount of malonaldehyde in the coronary effluent and a higher content of the endogenous antioxidants ascorbate and thiol. Significant induction of the expression of ubiquitin mRNA was also found in the hearts of the CoQ10-fed group. The results of this study demonstrate that nutritional supplementation of CoQ10 renders the hearts resistant to ischemia-reperfusion injury, probably by reducing the oxidative stress.
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AHEART April 47/4
Munzenmaier, Diane H., and David R. Harder. Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. Am J Physiol Heart Circ Physiol 278: H1163–H1167, 2000.—Cerebral microvascular endothelial cells (CMVEC) form tubes when cocultured with astrocytes (AS). Therefore, it appears that AS may be important in mediating angiogenesis in the brain. We ...
متن کاملAHEART April 47/4
Wang, Yan, and Yoram Rudy. Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Am J Physiol Heart Circ Physiol 278: H1019–H1029, 2000.—Heterogeneity of myocardial structure and membrane excitability is accentuated by pathology and remodeling. In this study, a detailed model of the ventricular myocyte in a multicellular fiber was used t...
متن کاملAHEART February 47/2
DAVID FULTON,1 ANDREAS PAPAPETROPOULOS,1 XIAOPING ZHANG,2 JOHN D. CATRAVAS,3 THOMAS H. HINTZE,2 AND WILLIAM C. SESSA1 1Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536-0812; 2Department of Physiology, New York Medical College, Valhalla, New York 10595; and 3Vascular Biology Center and Department of Pharmacology and...
متن کاملAHEART April 47/4
Kuoppala, Antti, Ken A. Lindstedt, Juhani Saarinen, Petri T. Kovanen, and Jorma O. Kokkonen. Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma. Am J Physiol Heart Circ Physiol 278: H1069–H1074, 2000.—Because bradykinin (BK) appears to have cardioprotective effects ranging from improved hemodynamics to antiproliferative effects, inhibition of B...
متن کاملAHEART April 47/4
Landesberg, Amir, and Samuel Sideman. Force-velocity relationship and biochemical-to-mechanical energy conversion by the sarcomere. Am J Physiol Heart Circ Physiol 278: H1274–H1284, 2000.—The intracellular control mechanism leading to the well-known linear relationship between energy consumption by the sarcomere and the generated mechanical energy is analyzed here by coupling calcium kinetics w...
متن کاملAHEART April 47/4
Frame, Mary D. Increased flow precedes remote arteriolar dilations for some microapplied agonists. Am J Physiol Heart Circ Physiol 278: H1186–H1195, 2000.—This study asks which occurs first in time for remote responses: a dilation or a remote change in flow. Arteriolar diameter (,20 μm) and fluorescently labeled red blood cell (RBC) velocity were measured in the cremaster muscle of anesthetized...
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تاریخ انتشار 2000